What is the catalog number for CD155/PVR Protein, Mouse, Recombinant (mFc Tag)?

The catalog number for CD155/PVR Protein, Mouse, Recombinant (mFc Tag) is PM53013M4.

What sizes are available for CD155/PVR Protein, Mouse, Recombinant (mFc Tag)?

CD155/PVR Protein, Mouse, Recombinant (mFc Tag) is available in the following size(s): 50 µg, 1 mg.

How many pack sizes does CD155/PVR Protein, Mouse, Recombinant (mFc Tag) come in?

CD155/PVR Protein, Mouse, Recombinant (mFc Tag) is available in 2 different pack sizes.

Is CD155/PVR Protein, Mouse, Recombinant (mFc Tag) in stock?

CD155/PVR Protein, Mouse, Recombinant (mFc Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

CD155/PVR Protein, Mouse, Recombinant (mFc Tag)

Product Specifications

Background

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

Overview

A DNA sequence encoding the mouse PVR (NP_081790.1) (Met1-Arg345) was expressed with the Fc region of mouse IgG2a at the C-terminus.

Synonyms

3830421F03Rik Protein, Mouse; CD155 Protein, Mouse; D7Ertd458e Protein, Mouse; HVED Protein, Mouse; mE4 Protein, Mouse; necl-5 Protein, Mouse; PVS Protein, Mouse; Taa1 Protein, Mouse; Tage4 Protein, Mouse

Gene Name

Poliovirus receptor

Expression System

HEK293 Cells

Tag

C-mFc

Field of Research

Cancer Drug Targets

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Purity

> 95 % as determined by SDS-PAGE.

Activity

1. Measured by its binding ability in a functional ELISA. Immobilized TIGIT Protein, Human, Recombinant (ECD, His Tag) (Cat:PH52206M2) at 2 μg/ml (100 μl/well) can bind CD155/PVR Protein, Mouse, Recombinant (mFc Tag) (Cat:PM53013M4), the ECof CD155/PVR Protein, Mouse, Recombinant (mFc Tag) is 25-140 ng/mL. 2. Immobilized mouse CD155 (mFc Tag) (PM53013M4) at 2 μg/mL (100μL/well) can bind Mouse TIGIT-His, HPLC-verified (HPLC-PM53006M2), the ECof Mouse TIGIT-His, HPLC-verified (HPLC-PM53006M2) is 300-900 ng/mL.

Form

Lyophilized

Buffer

Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Function

CD Molecule proteins, Immune Checkpoint Proteins, Cancer proteins, Biological Target proteins, Immunotherapy proteins

Molecular Weight

The recombinant mouse PVR consists of 550 amino acids and predicts a molecular mass of 60.78 kDa.

Storage Conditions

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.