Nitrovin (hydrochloride)

Nitrovin hydrochloride is an antibacterial growth promoter. Nitrovin hydrochloride induces ROS-mediated non-apoptotic and apoptotic-like cell death by targeting TrxR1. Nitrovin hydrochloride has anticancer activity, with IC50 values of 1.31-6.60 μM for tumor and normal cells[1].

Product Specifications

CAS Number

[2315-20-0]

Product Name Alternative

Difurazon (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Apoptosis; Bacterial; TrxR

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/nitrovin-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=[N+](C1=CC=C(/C=C/C(/C=C/C2=CC=C([N+]([O-])=O)O2)=N\NC(N)=N)O1)[O-].[H]Cl

Molecular Formula

C14H13ClN6O6

Molecular Weight

396.74

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Zhao L, et al. Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1) . Biochem Pharmacol. 2023 Apr;210:115487.