BIBW 2992

EGFR, HER2 kinase inhibitor

Product Specifications

Background

BIBW 2992 is a potent and irreversible ErbB inhibitor. It has also been shown to inhibit EGFR/Neu.

CAS Number

850140-72-6

Product Name Alternative

Afatinib, N-[4-[ (3-chloro-4-fluorophenyl) amino]-7-[[ (3S) -tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4- (dimethylamino) -2-butenamide

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

>99%

Weight

0.005

Format

Crystalline solid

Solubility

Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml

Molecular Formula

C24H25ClFN5O3

Molecular Weight

485.9

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.

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