Genipin

Genipin ((+) -Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research[1][2].

Product Specifications

CAS Number

[6902-77-8]

Product Name Alternative

(+) -Genipin

UNSPSC

12352005

Hazard Statement

H301

Target

Autophagy

Type

Natural Products

Related Pathways

Autophagy

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Genipin.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL|H2O : 4 mg/mL (ultrasonic)

Smiles

O=C(C1=CO[C@@H](O)[C@@]2([H])[C@]1([H])CC=C2CO)OC

Molecular Formula

C11H14O5

Molecular Weight

226.23

Precautions

H301

References & Citations

[1]Ma C, et al. Genipin stimulates glucose transport in C2C12 myotubes via IRS-1 and calcium- dependent mechanism. J Endocrinol. 2012 Dec 20.|[2]Kim BC, et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70 (9) :1398-407.|[3]Ye D, et al. Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1. Epigenetics. 2018 Mar 9:1-22.|[4]Kim BC, et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70 (9) :1398-407.