4′-DTMP
4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli[1].
Product Specifications
CAS Number
[21253-58-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/4-dtmp.html
Concentration
10mM
Purity
97.85
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1OC
Molecular Formula
C13H16N4O3
Molecular Weight
276.30
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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