5,6,7-Trimethoxyflavone

5,6,7-Trimethoxyflavone is a flavonoid compound that can be isolated from plants Callicarpa japonica. 5,6,7-Trimethoxyflavone exhibits antiviral and anti-inflammatory activities through inhibition of NF-κB/AP-1/STAT signaling pathway[1][2].

Product Specifications

CAS Number

[973-67-1]

Product Name Alternative

Baicalein trimethyl ether

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AP-1; CMV; Enterovirus; HSV; NF-κB; STAT

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/5-6-7-trimethoxyflavone.html

Purity

98.76

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=C(OC)C(OC)=C13

Molecular Formula

C18H16O5

Molecular Weight

312.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Hayashi K, et al., Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir. J Antimicrob Chemother. 1997 Jun;39 (6) :821-4.|[2]Rim HK, et al., 5,6,7-trimethoxyflavone suppresses pro-inflammatory mediators in lipopolysaccharide-induced RAW 264.7 macrophages and protects mice from lethal endotoxin shock. Food Chem Toxicol. 2013 Dec;62:847-55.