Loxicodegol

Loxicodegol (Oxycodegol) is a first-in-class, long-acting, orally active, and selective mu-opioid agonist with structural properties that reduce its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists[1][2].

Product Specifications

CAS Number

1211231-76-3

Product Name Alternative

Oxycodegol; NKTR-181

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/loxicodegol.html

Solubility

10 mM in DMSO

Smiles

O[C@@]1(CC[C@H](OCCOCCOCCOCCOCCOCCOC)[C@]2([H])OC3=C4OC)[C@]52C3=C(C=C4)C[C@@]1([H])N(C)CC5

Molecular Formula

C31H49NO10

Molecular Weight

595.72

References & Citations

[1]Miyazaki T, et al. NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential. J Pharmacol Exp Ther. 2017;363 (1) :104-113. |[2]Gudin J, et al. Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS) . Pain Med. 2020;21 (7) :1347-1356.