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MLKL-IN-7

MLKL-IN-7 (compound 9) is a MLKL inhibitor, and shows anti-necroptosis activity in HT-29 cells with the IC50 of 148.4 nM[1].

Product Specifications

UNSPSC

12352005

Target

Mixed Lineage Kinase

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mlkl-in-7.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(S(=O)(NC2=NC=C3C=CC=CC3=N2)=O)C=C1)/C=C/C4=CC=C([N+]([O-])=O)S4

Molecular Formula

C21H15N5O5S2

Molecular Weight

481.50

References & Citations

[1]Tang Y, et al. Design, synthesis and anti-necroptosis activity of fused heterocyclic MLKL inhibitors. Bioorg Med Chem. Published online March 1, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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