PTPN6 Antibody / SHP-1
PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
UniProt
P29350
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human full-length PTPN6 protein was used as the immunogen for the PTPN6 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
CPTC-PTPN6-2
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the PTPN6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PTPN6 antibody is available for research use only.
Storage Conditions
Store the PTPN6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the PTPN6 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free PTPN6 antibody (clone CPTC-PTPN6-2) as confirmation of integrity and purity.
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