Recombinant Beta Catenin Antibody / Rabbit Monoclonal
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
UniProt
P35222
Host
Rabbit
Reactivity
Human
Immunogen
Beta Catenin protein was used as the immunogen for the recombinant beta Catenin antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CTNB1-1R
Type
Recombinant
Applications
IHC-P, IF, WB
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the recombinant beta Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant beta Catenin antibody is available for research use only.
Storage Conditions
Store the recombinant beta Catenin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface, cytoplasmic, cell junctions
Image Legend
Immunofluorescent staining of human HeLa cells with recombinant Beta Catenin antibody (clone CTNB1-1R, green) and Reddot nuclear stain (red) .
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