3- (4-Hydroxy-1-oxoisoindolin-2-yl) piperidine-2,6-dione

Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.

Product Specifications

CAS Number

[1061604-41-8]

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lenalidomide-4-oh.html

Purity

99.62

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(N(CC1=C2C=CC=C1O)C2=O)CC3)NC3=O

Molecular Formula

C13H12N2O4

Molecular Weight

260.25

Precautions

H302, H312, H315, H319

References & Citations

[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.