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Anti-POLR3GL Antibody Picoband®, HRP Conjugate

Selected Variant

A17067-1-HRP

Size: 100 µg/Vial

Boster Bio Anti-POLR3GL Antibody Picoband® catalog # A17067-1. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Polymerase (RNA) III (DNA ed) polypeptide G (32kD)-like also known as POLR3GL is a protein which in humans is encoded by the POLR3GL gene.Predicted to enable chromatin binding activity. Involved in transcription by RNA polymerase III. Located in nucleus. Part of RNA polymerase III complex.

Synonyms

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

Gene Name

kelch repeat and BTB domain containing 2

Gene ID

84265

UniProt

Q9BT43

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human POLR3GL recombinant protein (Position: R8-K156).

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

ELISA,IF,ICC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Beauregard-Lacroix, E., Salian, S., Kim, H., Ehresmann, S., D'Amours, G., Gauthier, J., Saillour, V., Bernard, G., Mitchell, G. A., Soucy, J. F., Michaud, J. L., Campeau, PM. A variant of neonatal progeroid syndrome, or Wiedemann-Rautenstrauch syndrome, is associated with a nonsense variant in POLR3GL. Europ. J. Hum. Genet. 28: 461-468, 2020. 2. Haurie, V., Durrieu-Gaillard, S., Dumay-Odelot, H., Da Silva, D., Rey, C., Prochazkova, M., Roeder, R. G., Besser, D., Teichmann, M. Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation. Proc. Nat. Acad. Sci. 107: 4176-4181, 2010. 3. Renaud, M., Praz, V., Vieu, E., Florens, L., Washburn, M. P., l'Hote, P., Hernandez, N. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Genome Res. 24: 37-51, 2014.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

24145 MW

Observed Molecular Weight

24 kDa

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.25-0.5 μg/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human<br> ELISA, 0.1-0.5 μg/ml, -<br>

Subcellular Location

Cul3-RING ubiquitin ligase complex.

Protein Name

Transmembrane protein 240

Price

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