CD11b Antibody / MAC-1 / ITGAM
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alpha-M (CD11b) combines with the Integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3) . Integrin alpha-M/beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Functional studies (order BSA/sodium azide-free format)
Host
Rat
Reactivity
Human, Mouse
Immunogen
B10 mouse spleen cells enriched for T lymphocytes were used as the immunogen for this CD11b antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
M1/70
Applications
FACS, IF, Functional studies
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the CD11b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD11b antibody is available for research use only.
Storage Conditions
Store the CD11b antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Location
Cell surface, cytoplasm
Image Legend
SDS-PAGE Analysis of Purified, BSA-Free CD11b Antibody (clone M1/70) . Confirmation of Integrity and Purity of the Antibody.
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