Aminopterin N-hydroxysuccinimide ester

Aminopterin N-hydroxysuccinimide ester (NHS-methotrexate) is an irreversible Methotrexate (HY-14519) influx carrier inhibitor. Aminopterin N-hydroxysuccinimide ester can be used for the research of rheumatoid arthritis and a number of cancers (such as acute lymphoblastic leukemia) [1][2].

Product Specifications

CAS Number

[98457-88-6]

Product Name Alternative

NHS-Methotrexate

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aminopterin-n-hydroxysuccinimide-ester.html

Smiles

NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C)C=N2.O=C4N(C(CC4)=O)O

Molecular Formula

C24H27N9O8

Molecular Weight

569.53

References & Citations

[1]Henderson GB, et al. Characterization of the multiple transport routes for methotrexate in L1210 cells using phthalate as a model anion substrate. J Membr Biol. 1985;85 (3) :263-268. |[2]Chiao JH, et al. RFC-1 gene expression regulates folate absorption in mouse small intestine. J Biol Chem. 1997;272 (17) :11165-11170.