PARP1 Antibody
Poly [ADP-ribose] polymerase 1 (PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Product Specifications
UniProt
P09874
Host
Mouse
Immunogen
A human recombinant partial protein (amino acids Q670-R858) was used as the immunogen for the PARP1 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Applications
WB, IHC-P, IF, FACS
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
Limitations
This PARP1 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6692811/datasheet/rq6273.pdf
CAS Number
9007-83-4
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