Presenilin 1 Antibody / PSEN1
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:10-1:50, Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:10-1:50 (1x10e6 cells), Western blot: 1:500-1:1000
UniProt
P49768
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 330-359 from the human protein was used as the immunogen for the Presenilin 1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, IHC-P, FACS, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Presenilin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Presenilin 1 antibody is available for research use only.
Storage Conditions
Aliquot the Presenilin 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Nuclear, cytoplasmic, cell membrane
Image Legend
Western blot testing of human 1) HeLa and 2) HL60 cell lysate with Presenilin 1 antibody. Predicted molecular weight ~53 kDa.
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