MCM2 Antibody
MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-2000, IHC (Paraffin) : 1:50-1:100
UniProt
P49736
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 649-677 from the human protein was used as the immunogen for this MCM2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the MCM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MCM2 antibody is available for research use only.
Storage Conditions
Aliquot the MCM2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the MCM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Xenopus
Image Legend
Frequently Asked Questions
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