ER Antibody (isoform 4)
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P03372-4
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 283-312 from the human protein was used as the immunogen for this ER antibody (isoform 4) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ER antibody (isoform 4) and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ER antibody (isoform 4) is available for research use only.
Storage Conditions
Aliquot the ER antibody (isoform 4) and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ER antibody (isoform 4) may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
ER antibody (isoform 4) western blot analysis in SK-BR-3 lysate. Predicted molecular weight: 36 kDa.
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