MDS1 Antibody
MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon (s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q13465
Host
Rabbit
Reactivity
Mouse
Immunogen
A portion of amino acids 81-109 from the human protein was used as the immunogen for this MDS1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the MDS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MDS1 antibody is available for research use only.
Storage Conditions
Aliquot the MDS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the MDS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
MDS1 antibody western blot analysis in mouse NIH3T3 lysate.
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Frequently Asked Questions
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