PROTAC NCOA4 degrader-1

PROTAC NCOA4 degrader-1 is a VHL-based PROTAC NCOA4 degrader. PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces Fe2+ elevation, ROS production, MDA content and PTGS2 mRNA expression. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model. PROTAC NCOA4 degrader-1 can be used for the researches of inflammation and immunology. (Pink: NCOA4 ligand (HY-149457) . Black: linker (HY-163903) . Blue: VHL ligand (HY-138678B) ) [1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; PROTACs; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/protac-ncoa4-degrader-1.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CCN(C2=CC3=C(N=C(C4=CC(N5CCC6=CC(OCCOCCOCCOCCNC(CCCC(N[C@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C=C8)C9=C(N=CS9)C)=O)=O)=O)=O)=CC=C6C5)=CC=C4)N3)C=C2)CC1

Molecular Formula

C62H80N10O9S

Molecular Weight

1141.43

References & Citations

[1]Jian’ai Ji, et al. Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition. Journal of Medicinal Chemistry 2024 67 (15), 12521-12533.