DWP-05195
DWP-05195 is a TRPV1 antagonist that can inhibit the pain signal transduction. DWP-05195 induces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells[1][2].
Product Specifications
CAS Number
904309-12-2
UNSPSC
12352005
Target
Apoptosis; TRP Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dwp-05195.html
Smiles
FC(F)(C1=CC=CN=C1C2=CC=C(C3=NC4=C(N3)C=C(Br)C=C4)N=C2)F
Molecular Formula
C18H10BrF3N4
Molecular Weight
419.20
References & Citations
[1]Wang YY, et, al. TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells. Cancers (Basel) . 2020 Jun 26;12 (6) :1702.|[2]Lee J, et, al. A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers. Drug Des Devel Ther. 2017 Apr 24:11:1301-1313.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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