1,4-DPCA

1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM[1][2].

Product Specifications

CAS Number

[331830-20-7]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-4-dpca.html

Concentration

10mM

Purity

98.36

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C1=CN=C2C3=NC=CC=C3C=CC2C1=O)O

Molecular Formula

C13H8N2O3

Molecular Weight

240.21

References & Citations

[1]Yong Zhang, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7 (290) :290ra92.|[2]Ryan J Love, et al. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly (lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101 (12) :3599-606.|[3]Gaofeng Xiong, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1.