Azepexole (hydrochloride)

Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC50 of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy[1][2].

Product Specifications

CAS Number

[147663-20-5]

Product Name Alternative

B-HT 933 (hydrochloride) ; Oxazoloazepin (hydrochloride)

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/azepexole-hydrochloride.html

Purity

99.89

Solubility

10 mM in DMSO

Smiles

CCN(CC1)CCC2=C1OC(N)=N2.Cl

Molecular Formula

C9H16ClN3O

Molecular Weight

217.70

References & Citations

[1]Altamirano-Espinoza AH, et al. Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol. 2015;117 (1) :31-38. |[2]Capey S. Azepexole[J]. 2007.Pharm: The Comprehensive Pharmacology Reference.