EEDQ
EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM) . EEDQ inhibits contralateral rotation behavior[1][2][3][4][5].
Product Specifications
CAS Number
16357-59-8
Product Name Alternative
EEDQ
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; Biochemical Assay Reagents; Dopamine Transporter
Type
Biochemical Assay Reagents
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eedq.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C(OCC)C=CC2=C1C=CC=C2)OCC
Molecular Formula
C14H17NO3
Molecular Weight
247.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Hughes B P, et al. Effects of N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) on agonist-stimulated Ca2+ inflow across the hepatocyte plasma membrane. Biochemical pharmacology, 1991, 41 (6-7) : 1087-1090. |[2]Ni YG, et al. Irreversible antagonism of 5HT2c receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) . Proc Natl Acad Sci U S A. 1997 Mar 18;94 (6) :2715-8. |[3]Tarazi FI, et al. Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ. Neuropharmacology. 2000 Aug 23;39 (11) :2133-8. |[4]Goodale DB, et al. Selective protection from the inhibition by EEDQ of D1 and D2 dopamine agonist-induced rotational behavior in mice. Pharmacol Biochem Behav. 1988 Jun;30 (2) :457-62.|[5]Mestlin M, et al. Ontogenetic differences in the effects of EEDQ on dopamine-mediated behaviors. Pharmacol Biochem Behav. 1993 Aug;45 (4) :797-802.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
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