RAGE antagonist peptide
Product Specifications
UNSPSC Description
RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities[1][2].
Target Antigen
Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rage-antagonist-peptide.html
Purity
98.81
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CC(C)C[C@@H](C(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Weight
1272.56
References & Citations
[1]Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18(16):4356-64.|[2]Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173(17):2600-13.Cell Commun Signal. 2023 May 1;21(1):86.|Int J Biol Sci. 2024 Jan 1;20(2):784-800.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2268/RAGE-antagonist-peptide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2268/RAGE-antagonist-peptide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1092460-91-7
Available Sizes
Curated Selection
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