RAGE antagonist peptide
RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities[1][2].
Product Specifications
CAS Number
1092460-91-7
UNSPSC
12352209
Target
Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rage-antagonist-peptide.html
Purity
98.81
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CC(C)C[C@@H](C(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C57H101N13O17S
Molecular Weight
1272.55
References & Citations
[1]Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18 (16) :4356-64.|[2]Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173 (17) :2600-13.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Adv Biol (Weinh) . 2025 Jun 4:e00761.|Cell Commun Signal. 2023 May 1;21 (1) :86.|J Immunol. 2025 Jun 28:vkaf125.|Int J Biol Sci. 2024 Jan 1;20 (2) :784-800.
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