1,3-PBIT (dihydrobromide)
1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
Product Specifications
CAS Number
200716-66-1
UNSPSC
12352005
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-3-pbit-dihydrobromide.html
Smiles
NC(SCCC1=CC(CCSC(N)=N)=CC=C1)=N.Br.Br
Molecular Formula
C12H20Br2N4S2
Molecular Weight
444.25
References & Citations
[1]Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J. Biol. Chem. 269 (43), 26669-26676 (1994) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2856361 100 µL
Plasma kallikrein light chain Rabbit pAb, AE conjugated
Sign In for Pricing
View Details MBS1030502-01 1 mg (E-Coli)
Recombinant Eryx jaculus Cytochrome b (MT-CYB), partial
Sign In for Pricing
View Details MBS1030502-02 1 mg (Yeast)
Recombinant Eryx jaculus Cytochrome b (MT-CYB), partial
Sign In for Pricing
View Details