CD279 [PD-1] non-lytic Recombinant Protein
Product Specifications
Background
Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1) . CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
CAS Number
9000-83-3
NCBI Gene ID
5133
Swiss Prot
P22301
Accession Number
NP_005009
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Programmed cell death 1
NCBI Organism
Homo sapiens
Other Product Names
PD-1, Programmed Cell Death Protein 1
Species
Human
Protein ID
167857792
Physical Properties
Lyophilized
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