CD83 Recombinant Protein
Product Specifications
Background
Mouse CD83 is a 30-35kDa member of the Siglec (or sialic-acid-binding immunoglobulin-like lectin) family of transmembrane proteins. CD83 is a primary marker for dendritic cells. It is also found on B cells, neutrophils, monocytes and macrophages. Except for dendritic cells, CD83 expression is often transient. CD83 binds to sialic acids on target cells. Membrane CD83 promotes T cell proliferation, particularly of CD8+ cytotoxic T cells. Soluble CD83 is immunosuppressive and blocks T cell activation. On monocytes, CD83 is suggested to drive monocytes into a fibrocyte phenotype. A lack of membrane-expressed CD83 leads to an unusual IL-4/ IL-10 producing CD4+ T cell phenotype.
NCBI Gene ID
12522
Swiss Prot
P09920
Accession Number
NP_033986
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Innate Immunity
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-404
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
CD83 antigen
NCBI Organism
Mus musculus
Species
Mouse
Protein ID
6753356
Physical Properties
Lyophilized
CAS Number
9000-83-3
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