IL-17 RE (155-454) Recombinant Protein

Product Specifications

Background

Interleukin-17 receptor E (IL-17 RE) is an orphan receptor of the IL-17 receptor family, also known as UNQ3056, PRO9877, IL-17 Receptor E. IL-17RE is known to be expressed in the pancreas, brain, and prostate. IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C functioned in a unique autocrine manner, binding to a receptor complex consisting of the receptors IL-17RA and IL-17RE, which was preferentially expressed on tissue epithelial cells. Some data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.

CAS Number

9000-83-3

NCBI Gene ID

132014

Swiss Prot

Q8NFR9

Accession Number

NP_705613.1

Tag

Fc Tag

Type

Recombinant Proteins

Source

HEK293 cells

Purity

>95% as determined by SDS-PAGE.

Buffer

Tris with Glycine, Arginine and NaCl, pH7.5

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

60.5 kDa

Applications Notes

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.5 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.