JNJ525
JNJ525 (compound 1) is a TNFα inhibitor with the IC50 values of 1.2 μM and 1.1 μM against of TNFR1 and TNFR2, respectively[1].
Product Specifications
CAS Number
[2092913-64-7]
UNSPSC
12352005
Target
TNF Receptor
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Purity
99.93
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC=CC(N(CC2=CC=CC=C2)C3=C(C4=CC(C5=CN=C(N6CCNCC6)N=C5)=CC=C4)C=CC=C3)=N1
Molecular Formula
C31H30N8
Molecular Weight
514.62
References & Citations
[1]Blevitt JM, et al. Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. J Med Chem. 2017 Apr 27;60 (8) :3511-3517.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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