IGF binding protein 6 Recombinant Protein
Product Specifications
Background
Insulin-like growth factors (IGFs) comprise a family of endocrine, paracrine and autocrine polypeptides consisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs) and IGFBP proteases. Among the binding proteins, IGFBP6 is unique because of its N-terminal disulfide linkages and its marked binding preference for IGF2. It is a potent inhibitor of the interaction between IGF2 and its receptor IGF1R, thus preventing major functions of IGF2, such as induction of proliferation, differentiation, cell adhesion, or colony formation. In particular, IGFBP-6 inhibited the growth of neuroblastoma and rhabdomyosarcoma xenografts. GFBP-6 is expressed in many tissues, including lung, liver, gut and the central nervous system.
NCBI Gene ID
16012
Swiss Prot
P47880
Accession Number
P47880
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, EDTA, DTT, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-567
Calculated Molecular Weight
23.7 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Insulin-like growth factor binding protein 6
NCBI Organism
Mus musculus
Other Product Names
Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6, Igfbp6, IBP6, IGF binding protein 6
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1110643-06 0.02 mg (Mammalian-Cell)
Recombinant Borrelia duttonii GTPase Era (era)
Ask
View Details