HMGB1 Recombinant Protein
Product Specifications
Background
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
NCBI Gene ID
3146
Swiss Prot
P09429
Accession Number
NP_002119.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Innate Immunity, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-393
Calculated Molecular Weight
25.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
High mobility group box 1
NCBI Organism
Homo sapiens
Background Reference 01
Wang H, et al., 1999, Science 285 (5425) : 248–51.
Background Reference 02
Yang H, et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107 (26) : 11942–7.
Background Reference 03
Yang H, et al., 2010, Biochim. Biophys. Acta 1799 (1-2) : 149–56.
Background Reference 04
Fagone P, et al., 2011, Gene Ther. 18 (11) : 1070–7.
Other Product Names
HMGB1, HMG1, HMG3, SBP-1
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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