CD6 / TP120 Recombinant Protein

Product Specifications

Background

CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF) . CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. The majority of peripheral blood T cells, a subset of B cells, and a subset of neuronal cells express CD6. CD6 appears to play a role as both a costimulatory molecule in T cell activation and as an adhesion receptor. Studies demonstrating a mitogenic effect for T cells with some CD6 specific monoclonal antibodies, in conjunction with either accessory cells or PMA and anti-CD2 mAb, support the concept of CD6 as a co stimulatory molecule.

CAS Number

9000-83-3

NCBI Gene ID

923

Swiss Prot

P30203

Accession Number

NP_006716.3

Tag

His Tag

Type

Recombinant Proteins

Source

HEK293 cells

Field of Research

Cancer, Cell Cycle, Immunology, Innate Immunity, Signal Transduction

Purity

>90% as determined by SDS-PAGE.

Buffer

PBS, pH7.4

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

42.5 kDa

Applications Notes

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42.5 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.