CD38 Recombinant Protein
Product Specifications
Background
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
NCBI Gene ID
12494
Swiss Prot
P56528
Accession Number
NP_031672.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Homeostasis, Immunology, Obesity, Signal Transduction, Stem Cell
Purity
>90% as determined by SDS-PAGE.
Buffer
50 mM MES, 100 mM NaCl, pH6.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-441
Calculated Molecular Weight
31.7 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.7 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
CD38 antigen
NCBI Organism
Mus musculus
Background Reference 01
Orciani M., et al., 2008, J. Cell. Biochem. 105 (3) : 905–12.
Background Reference 02
Nata K., et al., 1997, Gene 186 (2) : 285–92.
Background Reference 03
Malavasi F., et al., 2008, Physiol. Rev. 88 (3) : 841–86.
Other Product Names
CD38, T10, cADPr hydrolase 1
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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