Antibacterial agent 241

Antibacterial agent 241 is a histidine kinase (HK) inhibitor, with IC50 values of 14 μM and 238 μM for CckA and PhoQ, respectively. Antibacterial agent 241 shows moderate antibacterial activity against E. coli DC2, Bacillus cereus, and Bacillus subtilis, with a MIC range of 12-74 μg/mL[1].

Product Specifications

CAS Number

[558638-15-6]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-241.html

Smiles

COC1=CC=C(C=C1)C2=C(NN=C2C3=C(C=C(C(Cl)=C3)O)O)C

Molecular Formula

C17H15ClN2O3

Molecular Weight

330.77

References & Citations

[1]Fernandez-Ciruelos B, et al. Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity. Microbiol Spectr. 2024 Aug 6;12 (8) :e0014624.