Cyclo (his-pro)

Cyclo (his-pro) (Cyclo (histidyl-proline) ) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo (his-pro) could inhibit NF-κB nuclear accumulation. Cyclo (his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].

Product Specifications

CAS Number

[53109-32-3]

Product Name Alternative

Cyclo (histidyl-proline) ; Histidylproline diketopiperazine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Cyclo_his-pro_.html

Purity

99.41

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 30 mg/mL

Smiles

O=C(N[C@H]1CC2=CN=CN2)[C@@](CCC3)([H])N3C1=O

Molecular Formula

C11H14N4O2

Molecular Weight

234.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Grottelli S, et al. The Role of Cyclo (His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17 (8) . pii: E1332.|[2]Minelli A, et al. Cyclo (His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44 (3) :525-35.|[3]Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo (His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.