GW-6604

GW-6604 is an ALK5 inhibitor with an IC50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis[1].

Product Specifications

CAS Number

[452342-37-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gw-6604.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(C2=NNC=C2C3=CC(C4=CC=CC=C4)=NC=C3)=CC=CC=N1

Molecular Formula

C19H14N4

Molecular Weight

298.34

Precautions

H302, H315, H319

References & Citations

[1]Anne-Charlotte de Gouville, et al. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. Br J Pharmacol. 2005 May;145 (2) :166-77.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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