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(Trp63, Trp64) ​-​C3a (63-77)

(Trp63, Trp64) ​-​C3a (63-77) is a C3a synthetic analogue peptide, which exhibits Ca2+ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC50 of 9.5, 2.0 and 0.8 nM, respectively[1].

Product Specifications

CAS Number

[130154-64-2]

UNSPSC

12352209

Target

Complement System

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/trp63-trp64-c3a-63-77.html

Purity

99.23

Solubility

DMSO : 2 mg/mL (ultrasonic)

Smiles

N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O

Molecular Formula

C86H134N26O18

Molecular Weight

1820.15

References & Citations

[1]Ames RS, et al., Evidence that the receptor for C4a is distinct from the C3a receptor. Immunopharmacology. 1997 Dec;38 (1-2) :87-92.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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