CYP17A1/HDAC6-IN-1
Product Specifications
UNSPSC Description
CYP17A1/HDAC6-IN-1 (compound 12) is a potent inhibitor of CYP17A1/HDAC6, with IC50 of 0.284μM and 0.6015 μM,respectively. CYP17A1/HDAC6-IN-1 has anti-tumor activity[1].
Target Antigen
Cytochrome P450; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyp17a1-hdac6-in-1.html
Solubility
10 mM in DMSO
Smiles
C[C@]12CCC3C(CC=C4C[C@@H](OC(CCCCCC(NO)=O)=O)CC[C@@]43C)C1CC=C2C5=CN=CC=C5
Molecular Weight
506.68
References & Citations
[1]Ram Sharma, et al. Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress. Cancer Lett. 2024 Feb 2:586:216666.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163359/CYP17A1-HDAC6-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163359/
Clinical Information
No Development Reported
Curated Selection
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