COH000
Product Specifications
Product Name Alternative
BMS-189453
UNSPSC Description
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro[1].
Target Antigen
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/COH000.html
Purity
98.0
Solubility
DMSO : 35.71 mg/mL (ultrasonic)
Smiles
CC(C=C1)=CC=C1C[C@@H](NC2=CC=CC=C2)[C@]34C(C(OC)=O)=C(C(OC)=O)[C@@H](O4)C=C3
Molecular Weight
419.47
References & Citations
[1]Li YJ, et al. Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Cell Chem Biol. 2018 Dec 5. pii: S2451-9456(18)30386-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114304/COH000-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114304/COH000-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1534358-79-6
Available Sizes
Curated Selection
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