SIGLEC11 Antibody (N-term) [APR04093G]
Product Specifications
Background
Tissue Location: Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia
Synonyms
Sialic acid-binding Ig-like lectin 11, Sialic acid-binding lectin 11, Siglec-11, SIGLEC11
Gene Name
SIGLEC11
Gene ID
114132
UniProt
Q96RL6
Chromosomal Location
Membrane; Single-pass type I membrane protein.
Applications
IHC-P, WB
Dilution
WB--1:500 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules.
Molecular Weight
75795
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIGLEC11 Antibody (N-term) [APR04093G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=114132
Uniprot URL
https://www.uniprot.org/uniprot/Q96RL6
Available Sizes
Curated Selection
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