GSDMC Antibody (Center) [APR03477G]

Product Specifications

Background

Tissue Location: Expressed mainly in trachea and spleen (PubMed:11223543) . In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GSDMC Antibody (Center) [APR03477G].

Synonyms

Gasdermin-C, Melanoma-derived leucine zipper-containing extranuclear factor, GSDMC, MLZE

Gene Name

GSDMC {ECO:0000303|PubMed:17350798, ECO:0000312|HGNC:HGNC:7151}

Gene ID

56169

UniProt

Q9BYG8

Chromosomal Location

[Gasdermin-C]: Cytoplasm, cytosol

Applications

WB, IHC-P, FC

Dilution

FC--1:25 WB--1:2000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

[Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death.