COPS7B Antibody (N-Term) [APR11649G]
Product Specifications
Synonyms
COP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b, COPS7B, CSN7B
Gene Name
COPS7B
Gene ID
64708
UniProt
Q9H9Q2
Chromosomal Location
Cytoplasm. Nucleus.
Applications
WB, FC, IHC-P
Dilution
IHC-P--1:100~500 FC--1:25 WB--1:2000
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Molecular Weight
29622
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COPS7B Antibody (N-Term) [APR11649G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=64708
Uniprot URL
https://www.uniprot.org/uniprot/Q9H9Q2
Available Sizes
Curated Selection
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