SPHK2 Antibody (C-term) [APS00021G]
Product Specifications
Background
Tissue Location: Mainly expressed in adult kidney, liver, and brain (PubMed:10751414) . Expressed in cerebral cortex and hippocampus (at protein level) (PubMed:29615132) . Isoform 1 is the predominant form expressed in most tissues (PubMed:16103110)
Synonyms
Sphingosine kinase 2, SK 2, SPK 2, SPHK2
Gene Name
HGNC:18859
Gene ID
56848
UniProt
Q9NRA0
Chromosomal Location
Cytoplasm. Nucleus. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9JIA7}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9JIA7}. Note=In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656) . In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132) . In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547) .
Applications
IHC-P-Leica, WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
19168031129546461611821920959514197296561295464616103110
Molecular Weight
69217
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SPHK2 Antibody (C-term) [APS00021G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=56848
Uniprot URL
https://www.uniprot.org/uniprot/Q9NRA0
Available Sizes
Curated Selection
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