What is the catalog number for Anti-Hu CD22 Pacific Blue™?

The catalog number for Anti-Hu CD22 Pacific Blue™ is PB-506-T100.

What sizes are available for Anti-Hu CD22 Pacific Blue™?

Anti-Hu CD22 Pacific Blue™ is available in the following size(s): 100 Tests.

Is Anti-Hu CD22 Pacific Blue™ in stock?

Anti-Hu CD22 Pacific Blue™ is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD22 Pacific Blue™?

Anti-Hu CD22 Pacific Blue™ is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD22 Pacific Blue™?

Estimated delivery time for Anti-Hu CD22 Pacific Blue™ is approximately 10 business day(s), depending on your location.

Anti-Hu CD22 Pacific Blue™

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human cell line Reh

Target Antigen

CD22

Clone

IS7

Applications

FC (QC tested)

Format

Pacific Blue

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Walker JA, Smith KG: CD22: an inhibitory enigma. Immunology. 2007 Dec 7, URL: https://www.ncbi.nlm.nih.gov/pubmed/18067554?ordin, *Tateno H, Li H, Schur MJ, Bovin N, Crocker PR, Wakarchuk WW, Paulson JC: Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol. 2007 Aug;27 (16) :5699-710., URL: https://www.ncbi.nlm.nih.gov/pubmed/17562860?ordin, *Tedder TF, Poe JC, Haas KM: CD22: A Multifunctional Receptor That Regulates B Lymphocyte Survival and Signal Transduction. Adv Immunol. 2005;88:1-50. , URL: https://www.ncbi.nlm.nih.gov/pubmed/16227086?ordin

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The antibody IS7 reacts with an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.