K02288
K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.
Product Specifications
CAS Number
[1431985-92-0]
UNSPSC
12352005
Hazard Statement
H301, H318
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/K02288.html
Concentration
10mM
Purity
99.65
Solubility
DMSO : ≥ 58.6 mg/mL
Smiles
OC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
Molecular Formula
C20H20N2O4
Molecular Weight
352.38
Precautions
H301, H318
References & Citations
[1]Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8 (4) :e62721.|[2]Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18 (2) :209-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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