What is the catalog number for Anti-Hu CD26 PE?

The catalog number for Anti-Hu CD26 PE is 1P-608-T100.

What sizes are available for Anti-Hu CD26 PE?

Anti-Hu CD26 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD26 PE in stock?

Anti-Hu CD26 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD26 PE?

Anti-Hu CD26 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD26 PE?

Estimated delivery time for Anti-Hu CD26 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD26 PE

CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

A human T cell clone

Target Antigen

CD26

Clone

BA5b

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Wong PT, Wong CK, Tam LS, Li EK, Chen DP, Lam CW: Decreased expression of T lymphocyte co-stimulatory molecule CD26 on invariant natural killer T cells in systemic lupus erythematosus. Immunol Invest. 2009;38 (5) :350-64., URL: https://www.ncbi.nlm.nih.gov/pubmed/19811413?ordin, *Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology. 2009 Oct;55 (4) :432-40., URL: https://www.ncbi.nlm.nih.gov/pubmed/19817894?ordin, *Kotacková L, Baláziová E, Sedo A: Expression pattern of dipeptidyl peptidase IV activity and/or structure homologues in cancer. Folia Biol (Praha) . 2009;55 (3) :77-84., URL: https://www.ncbi.nlm.nih.gov/pubmed/19545486?ordin, *Stremenova J, Krepela E, Mares V, Trim J, Dbaly V, Marek J, Vanickova Z, Lisa V, Yea C, Sedo A: Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade. Int J Oncol. 2007 Oct;31 (4) :785-92., URL: https://www.ncbi.nlm.nih.gov/pubmed/17786309?ordin, *Ellingsen T, Hornung N, Møller BK, Hjelm-Poulsen J, Stengaard-Pedersen K: In active chronic rheumatoid arthritis, dipeptidyl peptidase IV density is increased on monocytes and CD4 (+) T lymphocytes. Scand J Immunol. 2007 Oct;66 (4) :451-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/17850590?ordin

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody BA5b recognizes an extracellular epitope of CD26, a 110 kDa type II transmembrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.