Pyraclostrobin

Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases[1][2][3].

Product Specifications

CAS Number

[175013-18-0]

UNSPSC

12352005

Hazard Statement

H315, H331, H410

Target

AMPK; Autophagy; Bacterial; Bcl-2 Family; Beclin1; Fungal; mTOR

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pyraclostrobin.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(N(C1=C(C=CC=C1)COC2=NN(C3=CC=C(Cl)C=C3)C=C2)OC)=O

Molecular Formula

C19H18ClN3O4

Molecular Weight

387.82

Precautions

H315, H331, H410

References & Citations

[1]Wu M, et al. Characterization of hepatotoxic effects induced by pyraclostrobin in human HepG2 cells and zebrafish larvae [J]. Chemosphere, 2023, 340: 139732.|[2]Zhang C, et al. Acute and subchronic toxicity of pyraclostrobin in zebrafish (Danio rerio) [J]. Chemosphere, 2017, 188: 510-516.|[3]Li H, et al. Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae [J]. Environmental Pollution, 2019, 251: 203-211.