Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody
Product Specifications
Background
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5' -CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.
Abbreviation
Transcription Factor 7 Like 2
UniProt
Q9NQB0
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide of human TCF-4
Target
TCF7L2; HMG box transcription factor 4; HTCF-4; T-cell factor-4 variant X2; T-cell factor 4; Transcription factor 7-like 2; TCF-4
Clonality
Monoclonal
Clone
R09-1D1
Conjugation
Unconjugated
Applications
WB; IHC-P
Field of Research
Epigenetics and Nuclear Signaling; Cardiovascular; Metabolism
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:100
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
68kDa
Observed Molecular Weight
68kDa
Isotype
IgG
Available Sizes
Documents
Curated Selection
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