A-1248767
A-1248767 is a MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) with anticancer activity. A-1248767, a derivative of A-1210477 , binds to MCL-1 with high affinity, induces the increase of intracellular MCL-1 protein, and promotes tumor cell apoptosis[1].
Product Specifications
CAS Number
2228052-38-6
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-1248767.html
Smiles
O=C(N(C)C)N(CC1)CCN1C2=CC=C(OCC3=NN(C)C(C)=C3C4=C(N(CCN5CCOCC5)C(C(O)=O)=C6CCCOC7=C(C=CC=C8)C8=CC=C7)C6=CC=C4)C=C2
Molecular Formula
C47H55N7O6
Molecular Weight
813.98
References & Citations
[1]Leverson, et al. "Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) ." Cell death & disease 6.1 (2015) : e1590-e1590.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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