A-1248767

A-1248767 is a MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) with anticancer activity. A-1248767, a derivative of A-1210477 (HY-12468), binds to MCL-1 with high affinity, induces the increase of intracellular MCL-1 protein, and promotes tumor cell apoptosis[1].

Product Specifications

CAS Number

[2228052-38-6]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/a-1248767.html

Smiles

O=C(N(C)C)N(CC1)CCN1C2=CC=C(OCC3=NN(C)C(C)=C3C4=C(N(CCN5CCOCC5)C(C(O)=O)=C6CCCOC7=C(C=CC=C8)C8=CC=C7)C6=CC=C4)C=C2

Molecular Formula

C47H55N7O6

Molecular Weight

813.98

References & Citations

[1]Leverson, et al. "Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) ." Cell death & disease 6.1 (2015) : e1590-e1590.